Purpura from Quinine

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Blindness from quinine toxicity.

We report a case of quinine overdose in a 47-year-old man who presented with blindness. Fundus photography demonstrates the acute and subsequent retinal changes, and his visual recovery to normal acuity with visual field constriction is documented. Pupillary and electrodiagnostic findings are recorded. Stellate ganglion block has been widely advocated as a helpful therapeutic measure, but out p...

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Observations on cases of thrombocytopenic purpura due to quinine, sulphamezathine, and quinidine.

Toxic purpura occurring in persons who have previously been sensitized by drug-taking often manifests itself with great rapidity in a matter of a few hours. Thrombocytopenia which may accompany this type of purpura can also occur in a very short time. If the natural life-span of platelets is about five days (Lawrence and Valentine, 1947; Hirsch and Gardner, 1952) then this rapid onset of thromb...

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Quinine Bihydrochloride v. Quinine Bisulphate

come across a medical man who avers that it is a useless salt of Quinine and that the only salt of anv use for injection is the Bisulpliate of Quinine, Now, from what I can remember of the Physiology of the Blood, I should have thought that the Bisulpliate was a much more foreign salt to the plasma than the Bihydrochloride. As far as I can remember the plasma contains Chlorides in abundance, bu...

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Recovery from blindness following accidental quinine overdose

CASE A 46-year-old woman presented with sudden loss of vision in both eyes, apparent since waking. She also complained of partial hearing loss. The previous evening she had experienced difficulty sleeping due to (long-standing) restless legs and had self-medicated with quinine, taking an accidental overdose of 1.8 g. On admission, she was alert but unable to perceive light in either eye, and ha...

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Adulterated Quinine

Deaii Sir,?"With reference to a correspondence which appeared in the Mirror of 12th instant, from Bhobun IVIohun Sircar, drawing attention to an article in the August number of the Indian Medical Gazette on the adulteration of quinine, I beg to offer a few remarks on the subject, and to ask your opinion if it is the duty of the Health Officer to suppress those frauds which are committed by the ...

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ژورنال

عنوان ژورنال: The Boston Medical and Surgical Journal

سال: 1883

ISSN: 0096-6762,1533-4406

DOI: 10.1056/nejm188312201092506